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Which of the following is NOT used as a criterion to classify viruses?


A) morphology
B) nucleic acid
C) biochemical tests
D) size
E) number of capsomeres

F) A) and C)
G) A) and B)

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Most RNA viruses carry which of the following enzymes?


A) ATP synthase
B) DNA- dependent DNA polymerase
C) reverse transcriptase
D) RNA- dependent RNA polymerase
E) lysozyme

F) A) and B)
G) A) and C)

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Which of the following is most likely a product of an early gene?


A) spike proteins
B) DNA polymerase
C) lysozyme
D) envelope proteins
E) capsid proteins

F) B) and C)
G) D) and E)

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A viroid is a completely developed infectious agent composed of nucleic acid and surrounded by a capsid.

A) True
B) False

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Dogs do not get measles because their cells lack the correct receptor sites for that virus.

A) True
B) False

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Lysogeny can result in all of the following EXCEPT


A) immunity to reinfection by the same phage.
B) immunity to reinfection by any phage.
C) acquisition of new characteristics by the host cell.
D) phage conversion.
E) specialized transduction.

F) A) and E)
G) All of the above

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Bacteriophage replication differs from animal virus replication because only bacteriophage replication involves


A) injection of naked nucleic acid into the host cell.
B) replication of viral nucleic acid.
C) adsorption to specific receptors.
D) lysis of the host cell.
E) assembly of viral components.

F) A) and B)
G) A) and C)

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A clear area against a confluent "lawn" of bacteria is called a


A) plaque.
B) phage.
C) rash.
D) pock.
E) cell lysis.

F) C) and D)
G) C) and E)

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Which of the following is NOT utilized to culture viruses?


A) animal cell cultures
B) embryonated eggs
C) culture media
D) laboratory animals
E) bacterial cultures

F) C) and D)
G) B) and C)

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Most drugs that interfere with viral multiplication also interfere with host cell function.

A) True
B) False

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Oncogenic viruses


A) are genetically unstable.
B) cause acute infections.
C) have no effect on the host cell.
D) are lytic viruses that kill the host cell.
E) cause tumors to develop.

F) A) and D)
G) A) and B)

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Assume you have isolated an unknown virus. This virus has a single, positive sense strand of RNA, and possesses an envelope. To which group does it most likely belong?


A) togavirus
B) herpesvirus
C) picornavirus
D) papovavirus
E) retrovirus

F) A) and C)
G) A) and D)

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Continuous cell lines differ from primary cell lines in that


A) continuous cell lines always have to be re- isolated from animal tissues.
B) continuous cell lines can be maintained through an indefinite number of generations.
C) viruses can be grown in continuous cell lines.
D) continuous cell lines are from human embryos.
E) continuous cell lines are derived from primary cell lines.

F) A) and E)
G) C) and D)

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DNA made from an RNA template will be incorporated into the virus capsid of


A) Herpesviridae.
B) Retroviridae.
C) Hepadnaviridae.
D) influenzavirus.
E) bacteriophage families.

F) B) and D)
G) None of the above

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A persistent infection is one in which


A) viral replication is unusually slow.
B) the disease process occurs gradually over a long period.
C) the virus remains in equilibrium with the host without causing a disease.
D) host cells are gradually lysed.
E) host cells are transformed.

F) D) and E)
G) None of the above

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A lytic virus has infected a patient. Which of the following would best describe what is happening inside the patient?


A) The virus is infecting cells and then releasing only small amounts of virus.
B) The virus is not killing any cells in the host.
C) The virus is causing the death of the infected cells in the patient.
D) The virus is incorporating its nucleic acid with that of the patient's cells.
E) The virus is slowly killing the patient's cells.

F) A) and B)
G) A) and D)

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The definition of lysogeny is


A) the period during replication when virions are not present.
B) phage DNA is incorporated into host cell DNA.
C) attachment of a phage to a cell.
D) lysis of the host cell due to a phage.
E) when the burst time takes an unusually long time.

F) A) and C)
G) A) and B)

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Which of the following would be the first step in biosynthesis of a virus with a - (minus) strand of RNA?


A) synthesis of double- stranded RNA from a DNA template
B) synthesis of double- stranded RNA from an RNA template
C) synthesis of DNA from a DNA template
D) synthesis of DNA from an RNA template
E) transcription of mRNA from DNA

F) A) and E)
G) All of the above

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Which of the following statements about viral spikes is FALSE?


A) They are composed of carbohydrate- protein complexes.
B) They bind to receptors on the host cell surface.
C) They are used for attachment.
D) They are found only on nonenveloped viruses.
E) They may cause hemagglutination.

F) A) and E)
G) B) and D)

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A viral species is a group of viruses that


A) has the same genetic information and ecological niche.
B) has the same morphology and nucleic acid.
C) infects the same cells and cause the same disease.
D) cannot be defined.

E) B) and C)
F) C) and D)

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