Question 1

Which of the following is not part of the core promoter?

Accepted Answer

A)   the transcription start site
B)   the Pribnow box (−10 region) 
C)   the −35 region
D)   the UP elementE) A) and D)
F) None of the above

Question 2

The lariat mechanism has been demonstrated by observing the lariat structure using electron microscopy.

Accepted Answer

A) True 
 B)False  True

Question 3

The eukaryotic TATA-binding protein (TBP)  functions in a manner similar to

Accepted Answer

A)   sigma (σ)  factor in E. coli.
B)   rho (ρ)  factor in E. coli.
C)   lac I in E. coli.
D)   CAP in E. coli.E) A) and D)
F) B) and C)

Question 4

CREB contains the following structural motif:

Accepted Answer

A)   Helix-turn-helix
B)   β−barrel
C)   Zinc finger
D)   Leucine zipperE) B) and D)
F) None of the above D

Question 5

Which of the conditions would result in the greatest amount of transcription of the lac operon?   [glucose ] [lactose ] I.  high  high  II.  low  low  III.  high  low  IV.  low  high \begin{array} { l c c } & 	ext { [glucose } ] & 	ext { [lactose } ] \ 	ext { I. } & 	ext { high } & 	ext { high } \	ext { II. } & 	ext { low } & 	ext { low } \	ext { III. } & 	ext { high } & 	ext { low } \	ext { IV. } & 	ext { low } & 	ext { high }\end{array} I.  II.  III.  IV. ​ [glucose ] high  low  high  low ​ [lactose ] high  low  low  high ​

Accepted Answer

A)   I
B)   II
C)   III
D)   IV E) B) and C)
F) A) and C)

Question 6

The major difference between RNA initiation in eukaryotes and prokaryotes is the number of factors involved in the process.

Accepted Answer

A) True 
 B)False

Question 7

RNA synthesis begins at the base in the DNA sequence designated by the following number:

Accepted Answer

A)   +1 (plus one) 
B)   0 (zero) 
C)   −1 (minus one) 
D)   −10 region (minus ten) 
E)   It varies between genes.F) All of the above
G) C) and D)

Question 8

TATA-binding protein (TBP)  is normally required for transcription by

Accepted Answer

A)   Pol I.
B)   Pol II.
C)   Pol III.
D)   all of these polymerases.
E)   none of these polymerasesF) None of the above
G) A) and E)

Question 9

Which of the following transcription factors is involved in the elongation phase of eukaryotic transcription?

Accepted Answer

A)   TFIIA
B)   TFIID
C)   TFIIF
D)   There are no transcription factors associated with elongation.E) A) and B)
F) A) and C)

Question 10

RNA transcribed from the coding strand instead of the template strand

Accepted Answer

A)   is called antisense RNA.
B)   produces histones.
C)   is tRNA.
D)   never occurs.E) A) and D)
F) B) and C)

Question 11

Which enzyme transcribes genes encoding tRNA in eukaryotes?

Accepted Answer

A)   RNA polymerase I
B)   RNA polymerase II
C)   RNA polymerase III
D)   Different tRNAs are transcribed by different RNA polymerases.E) All of the above
F) A) and C)

Question 12

Ribozymes, the catalytic activity of RNA, were first discovered as part of the snRNA group.

Accepted Answer

A) True 
 B)False

Question 13

Which of the following is not true about RISC?

Accepted Answer

A)   It is only involved in cleaving dsRNA from viruses
B)   It is involved with processing of miRNA and siRNA
C)   It uses a protein from the argonaut family
D)   It unwinds dsRNA and eventually discards the passenger strandE) A) and D)
F) C) and D)

Question 14

Operons

Accepted Answer

A)   control the expression of constitutive genes.
B)   are subject to positive or to negative control.
C)   are not affected by mutations in the genes for repressors or inducers.
D)   occur in both prokaryotes and eukaryotes.E) All of the above
F) A) and B)

Question 15

Which of the following is not true?

Accepted Answer

A)   The mechanism of activation of eukaryotic genes involves addition and removal of phosphate residues from some of the transcription factors.
B)   In plants, there are 5 RNA polymerases.
C)   RNA Pol IV is the primary RNA synthesizer in plants
D)   Of the RNA Polymerases in eukaryotes, Pol II is the most extensively studied.E) B) and C)
F) All of the above

Question 16

Response elements

Accepted Answer

A)   are similar to operons in that they are controlled by a single promoter
B)   are enhancers of transcription activated by metabolic factors
C)   are not affected by steroids
D)   are silencers of transcription triggered by the presence of metal ionsE) A) and D)
F) A) and C) B

Question 17

Which of following statements describes a difference between replication of DNA and transcription of RNA?

Accepted Answer

A)   Nucleoside triphosphates are the precursors for replication, but nucleoside diphosphates are used for transcription.
B)   Both strands of DNA are copied in replication, but usually only one is copied in transcription.
C)   Base pairing is used to copy the sequence in replication, but not in transcription.
D)   The chain grows from the 5' to the 3' end in replication, but 3' to 5' in transcription.
E)   None of theseF) B) and E)
G) A) and C)

Question 18

Phosphorylation of the CTD of RNA polymerase II occurs during which phase of transcription?

Accepted Answer

A)   initial binding to the promoter
B)   conversion from the closed complex to the open complex
C)   termination of transcription
D)   None of theseE) B) and D)
F) B) and C)

Question 19

The sequences in eukaryotic DNA known as introns are

Accepted Answer

A)   those included in the final sequence of messenger RNA
B)   the intervening sequences not expressed in the final sequence of messenger RNA
C)   the binding sites for DNA polymerase
D)   the binding sites for RNA polymeraseE) B) and D)
F) All of the above

Question 20

General transcription activation in eukaryotes requires

Accepted Answer

A)   a specific enhancer common to all genes
B)   a specific silencer common to all genes
C)   a protein called Mediator
D)   a CREB binding protein
E)   none of theseF) C) and D)
G) B) and E)

Exam 11: Transcription of the Genetic Code: Biosynthesis of RNA

Which of the following is not part of the core promoter?

Correct Answer
verified

The lariat mechanism has been demonstrated by observing the lariat structure using electron microscopy.

Correct Answer
verified
True

The eukaryotic TATA-binding protein (TBP) functions in a manner similar to

Correct Answer
verified

CREB contains the following structural motif:

Correct Answer
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D

Correct Answer
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The major difference between RNA initiation in eukaryotes and prokaryotes is the number of factors involved in the process.

Correct Answer
verified

RNA synthesis begins at the base in the DNA sequence designated by the following number:

Correct Answer
verified

TATA-binding protein (TBP) is normally required for transcription by

Correct Answer
verified

Which of the following transcription factors is involved in the elongation phase of eukaryotic transcription?

Correct Answer
verified

RNA transcribed from the coding strand instead of the template strand

Correct Answer
verified

Which enzyme transcribes genes encoding tRNA in eukaryotes?

Correct Answer
verified

Ribozymes, the catalytic activity of RNA, were first discovered as part of the snRNA group.

Correct Answer
verified

Which of the following is not true about RISC?

Correct Answer
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Operons

Correct Answer
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Which of the following is not true?

Correct Answer
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Response elements

Correct Answer
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B

Which of following statements describes a difference between replication of DNA and transcription of RNA?

Correct Answer
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Phosphorylation of the CTD of RNA polymerase II occurs during which phase of transcription?

Correct Answer
verified

The sequences in eukaryotic DNA known as introns are

Correct Answer
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General transcription activation in eukaryotes requires

Correct Answer
verified

Exam 11: Transcription of the Genetic Code: Biosynthesis of RNA

Which of the following is not part of the core promoter?

Correct AnswerverifiedShow Answer

The lariat mechanism has been demonstrated by observing the lariat structure using electron microscopy.

Correct AnswerverifiedTrue

The eukaryotic TATA-binding protein (TBP) functions in a manner similar to

Correct AnswerverifiedShow Answer

CREB contains the following structural motif:

Correct AnswerverifiedD

Correct AnswerverifiedShow Answer

The major difference between RNA initiation in eukaryotes and prokaryotes is the number of factors involved in the process.

Correct AnswerverifiedShow Answer

RNA synthesis begins at the base in the DNA sequence designated by the following number:

Correct AnswerverifiedShow Answer

TATA-binding protein (TBP) is normally required for transcription by

Correct AnswerverifiedShow Answer

Which of the following transcription factors is involved in the elongation phase of eukaryotic transcription?

Correct AnswerverifiedShow Answer

RNA transcribed from the coding strand instead of the template strand

Correct AnswerverifiedShow Answer

Which enzyme transcribes genes encoding tRNA in eukaryotes?

Correct AnswerverifiedShow Answer

Ribozymes, the catalytic activity of RNA, were first discovered as part of the snRNA group.

Correct AnswerverifiedShow Answer

Which of the following is not true about RISC?

Correct AnswerverifiedShow Answer

Operons

Correct AnswerverifiedShow Answer

Which of the following is not true?

Correct AnswerverifiedShow Answer

Response elements

Correct AnswerverifiedB

Which of following statements describes a difference between replication of DNA and transcription of RNA?

Correct AnswerverifiedShow Answer

Phosphorylation of the CTD of RNA polymerase II occurs during which phase of transcription?

Correct AnswerverifiedShow Answer

The sequences in eukaryotic DNA known as introns are

Correct AnswerverifiedShow Answer

General transcription activation in eukaryotes requires

Correct AnswerverifiedShow Answer

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True

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D

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B

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