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The multidrug-resistant pumps in many bacterial cell membranes function by ________.


A) bacterial chromosomal mutations
B) synthesis of enzymes that alter drug structure
C) removing the drug from the cell when it enters
D) alteration of drug receptors on cell targets
E) All of the choices are correct.

F) B) and E)
G) All of the above

Correct Answer

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Gram-negative rods are often treated with ________.


A) penicillin G
B) vancomycin
C) aminoglycosides
D) synercid
E) isoniazid

F) D) and E)
G) A) and D)

Correct Answer

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Fluoroquinolones such as ciprofloxacin,are synthetic drugs that interfere with the action of DNA helicases.  This means that ________.


A) the bacterial cell will die since it cannot replicate or transcribe its DNA
B) binary fission cannot take place because the cell cannot make proteins
C) the bacterial cell will die since it cannot take in nutrients across the cell membrane
D) the cell will die because it cannot make folic acid,which is a precursor to DNA and RNA,as well as amino acids

E) All of the above
F) None of the above

Correct Answer

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Which antimicrobial does not inhibit cell wall synthesis?


A) Gentamicin
B) Vancomycin
C) Cephalosporins
D) Penicillins
E) Bacitracin

F) B) and E)
G) All of the above

Correct Answer

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A 76-year-old male visits his primary care physician with complaints of burning with urination and a frequent urge to void. The RN aids the patient in collecting a urine specimen to be sent for analysis. While awaiting the final results of drug susceptibility testing in the lab, the patient is prescribed oral sulfasoxazole. -You provide education to the patient regarding sulfasoxazole,a sulfonamide that targets folic acid synthesis.The synthesis of which of the following products is affected by inhibition of folate metabolism?  


A) DNA
B) RNA
C) DNA and RNA
D) DNA,RNA,and amino acids

E) B) and C)
F) A) and D)

Correct Answer

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A clinical microbiologist makes serial dilutions of several antimicrobials in broth,and then incubates each drug dilution series with a standard amount of a patient's isolated pathogen.What is this microbiologist setting up?


A) Kirby-Bauer
B) Antibiogram
C) E-test
D) MIC
E) Therapeutic index (TI)

F) A) and C)
G) A) and B)

Correct Answer

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Which newer synthetic drug is used to treat MRSA and VRE infections?


A) Synercid
B) Clindamycin
C) Linezolid
D) Azithromycin
E) Clarithromycin

F) A) and E)
G) B) and D)

Correct Answer

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A ratio of the dose of a drug that is toxic to humans versus the minimum effective dose for that pathogen is assessed to predict the potential for toxic drug reactions.This is called the ________.


A) Kirby-Bauer
B) antibiogram
C) E-test
D) MIC
E) therapeutic index (TI)

F) C) and E)
G) C) and D)

Correct Answer

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An antimicrobial with a low therapeutic index is a safer choice compared to a drug with a high therapeutic index.

A) True
B) False

Correct Answer

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Each of the following affect cell walls except ________.


A) penicillin
B) isoniazid
C) vancomycin
D) erythromycin
E) cephalosporin

F) A) and E)
G) A) and B)

Correct Answer

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Micafungin and caspofungin are antifungal drugs that inhibit cell wall synthesis.  They belong to the group of drugs known as ________.


A) echinocandins
B) macrolide polyenes
C) azoles
D) allylamines

E) B) and C)
F) C) and D)

Correct Answer

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Drugs with high selective toxicity include ________.


A) ampicillin and bacitracin
B) amphotericin B and fluconazole
C) mebendazole and albendazole
D) quinine and metronidazole

E) All of the above
F) C) and D)

Correct Answer

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A

A 12-year-old male is admitted to the pediatric unit due to persistent upper respiratory symptoms and respiratory distress. The patient has a history of developmental delay, chronic lung disease, and frequent respiratory infections. Upon assessment, the RN notes the patient to have a fever, moderate respiratory rate, productive cough, and large amount of nasal secretions. Upon report from the patient's mother, the patient has been on a 3-week course of antibiotics with no improvement in symptoms. The medical team completes a respiratory infection workup and the patient is diagnosed with bacterial pneumonia and methicillin-resistant Staphylococcus aureus (MRSA) superinfection. -The RN provides education to the patient and his mother regarding the diagnosis.Which of the following statements by the mother demonstrates a proper understanding of the teaching?  


A) My son has an extremely resistant form of MRSA causing his prolonged illness.
B) My son developed simultaneous bacterial infections and his antibiotics were not treating his MRSA infection.
C) My son developed a MRSA superinfection following suppression of normal resident species in his lungs by the antibiotics he was taking to treat his initial infection.
D) My son has pneumonia caused by a virus.

E) A) and C)
F) B) and C)

Correct Answer

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Which antimicrobial does not interfere with protein synthesis?


A) Aminoglycosides
B) Tetracyclines
C) Erythromycin
D) Trimethroprim
E) Gentamicin

F) A) and E)
G) B) and D)

Correct Answer

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Bacteria can have a natural resistance to a drug that it has never been exposed to.

A) True
B) False

Correct Answer

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Which drug is used to treat cases of tuberculosis?


A) Penicillin G
B) Vancomycin
C) Tetracycline
D) Synercid
E) Isoniazid

F) B) and E)
G) A) and E)

Correct Answer

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What cell wall inhibiting drug is used in cases of penicillin and methicillin resistance?


A) Penicillin G
B) Vancomycin
C) Tetracycline
D) Erythromycin
E) Isoniazid

F) A) and C)
G) B) and E)

Correct Answer

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B

Mebendazole is a drug used to treat ________ infections.


A) bacterial
B) fungal
C) protozoan
D) helminthic
E) viral

F) C) and D)
G) All of the above

Correct Answer

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Antimicrobials that are effective against a wide variety of microbial types are termed ________.


A) antibiotics
B) narrow-spectrum drugs
C) semisynthetic drugs
D) synthetic drugs
E) broad-spectrum drugs

F) A) and D)
G) All of the above

Correct Answer

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E

Substances that are naturally produced by certain microorganisms that can inhibit or destroy other microorganisms are called ________.


A) antibiotics
B) narrow-spectrum drugs
C) semisynthetic drugs
D) synthetic drugs
E) broad-spectrum drugs

F) B) and E)
G) A) and B)

Correct Answer

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